Compounded semaglutide.

What compounded semaglutide is used for

Semaglutide is a GLP-1 receptor agonist. Through the edit, compounded semaglutide may be prescribed, when clinically appropriate, to support weight management alongside a reduced-calorie diet and regular physical activity. It is available by prescription only, after an evaluation with a licensed provider.

Who should not use semaglutide

Do not use semaglutide if you or a family member has ever had medullary thyroid carcinoma (MTC), or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Semaglutide is also not appropriate if you have had a serious allergic reaction to semaglutide or any of its ingredients.

Tell your provider about your complete medical history, including any history of pancreatitis, gallbladder disease, kidney problems, diabetic retinopathy, or severe gastrointestinal conditions such as gastroparesis.

Possible thyroid tumors, including cancer

In animal studies, semaglutide caused thyroid C-cell tumors. It is not known whether semaglutide causes these tumors, including medullary thyroid carcinoma, in people. Tell your provider right away if you notice a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

Pancreatitis

Inflammation of the pancreas, including serious cases, has been reported with GLP-1 receptor agonist medications. Stop using semaglutide and get medical help right away if you have severe pain in your upper stomach area that does not go away, with or without vomiting. The pain may spread to your back.

Gallbladder problems

Gallbladder problems, including gallstones, have occurred in people using GLP-1 medications, and some cases required surgery. Contact your provider if you develop pain in your upper right abdomen, fever, yellowing of the skin or eyes, or clay-colored stools.

Low blood sugar with insulin or sulfonylureas

Using semaglutide with insulin or with medications that increase insulin release, called sulfonylureas, raises the risk of low blood sugar. Symptoms can include shakiness, sweating, dizziness, hunger, fast heartbeat, confusion, and blurred vision.

Tell your provider about every diabetes medication you take. Doses may need to be adjusted to lower this risk.

Kidney problems

Nausea, vomiting, or diarrhea can lead to dehydration, which can worsen kidney function. Kidney injury has been reported with GLP-1 medications, including in people who had no prior kidney disease. Stay hydrated during treatment, and contact your care team if you cannot keep fluids down.

Diabetic retinopathy complications

If you have a history of diabetic retinopathy, rapid improvements in blood sugar have been associated with a temporary worsening of the condition. Tell your provider about any history of diabetic eye disease before starting, and report any changes in your vision during treatment.

Serious allergic reactions

Serious allergic reactions, including anaphylaxis and angioedema, have been reported with semaglutide. Stop using the medication and seek emergency care if you develop swelling of your face, lips, tongue, or throat, trouble breathing or swallowing, severe rash, rapid heartbeat, or fainting.

Pregnancy and breastfeeding

Semaglutide should not be used during pregnancy, as it may harm a developing baby. If you are planning a pregnancy, talk with your provider about stopping semaglutide at least two months in advance.

It is not known whether semaglutide passes into breast milk. Talk with your provider before using semaglutide while breastfeeding.

Common side effects

The most common side effects are gastrointestinal: nausea, vomiting, diarrhea, constipation, stomach pain, and decreased appetite. These are usually most noticeable when starting treatment or increasing your dose, and they often ease over time.

Tell your care team if side effects are severe or do not improve. Your provider may adjust your plan.

Drug interactions

Semaglutide slows stomach emptying, which can change how some oral medications are absorbed. It can also add to the blood-sugar-lowering effect of insulin and sulfonylureas.

Share a complete list of your prescriptions, over-the-counter medications, and supplements during your consultation so your provider can review potential interactions.

Compounded medication disclosure

Semaglutide is the active ingredient in the FDA-approved medications Ozempic and Wegovy. Compounded semaglutide is not affiliated with, endorsed by, or a substitute for those products.

Compounded semaglutide prescribed through the edit is prepared by The Pharmacy Hub, a licensed U.S. pharmacy, and shipped in temperature-controlled packaging.

When to seek immediate care

Call 911 or go to the nearest emergency room if you experience signs of a serious allergic reaction, severe stomach pain that does not go away, or symptoms of severe low blood sugar such as confusion, seizure, or loss of consciousness.

Contact your provider promptly for a lump or swelling in your neck, hoarseness, vision changes, upper right abdominal pain with fever or yellowing of the skin, or an inability to keep fluids down.

Questions

Your care team is here for you. Email hello@theedithealth.com or send a secure message through the member portal at my.theedithealth.com, and a member of your care team will follow up.