Estradiol

CompoundedWomen's healthEstrogen
Starting at $69 / month

Estradiol is a form of estrogen, the hormone that declines through perimenopause and menopause. A compounded estradiol protocol is prescribed and dosed by a licensed provider, in the form that fits you: transdermal patch, daily gel, oral tablet, or vaginal cream.

Choose your form

The system

Your provider helps you choose the delivery that fits your routine and history: patch, gel, tablet, or vaginal cream.

Full refund if you are not approved. Prescriptions are issued only if a licensed provider determines treatment is appropriate for you.

  • Prescription medication
  • Choice of delivery form
  • Clinician visit & ongoing care
  • Temperature-controlled 2-day shipping
What it treats

More than hot flashes.

As estrogen declines through perimenopause and menopause, the effects reach well beyond hot flashes. Estradiol is used to relieve the symptoms driven by that decline.

Hot flashes & night sweatsBroken sleepBrain fogMood changesVaginal drynessLow libido
Benefits

What it gives back.

Steadier days

Fewer hot flashes and night sweats getting in your way.

Clearer thinking

Less brain fog, more focus through the day.

Better sleep

Nights that feel like real rest again.

Feeling like yourself

Mood and energy that hold steadier.

Who it's for

Perimenopause and menopause.

Perimenopause is the transition before your final period, when estrogen and progesterone begin to fluctuate and decline. Menopause is the point twelve months after your last period. Estrogen affects nearly every system in the body, which is why its decline can be felt in so many ways at once.

Why estradiol. Estradiol replaces the estrogen your body is making less of, addressing the source of many symptoms rather than masking them one at a time. A licensed provider chooses the form and dose for you and adjusts it over time.

FAQ

Common questions.

Find out more about Estradiol.

Estradiol replaces the estrogen your body makes less of during the menopause transition. Your provider selects the delivery and dose, and adjusts over time based on how you feel.

Patch, gel, tablet, and vaginal cream each suit different routines and needs. A patch is low-maintenance, gel is flexible, tablets are familiar, and vaginal cream targets local comfort. Your provider recommends the fit.

Estrogen therapy can cause breast tenderness, spotting, headache, or nausea, especially early on. Your provider reviews your history and monitors your response.

Estrogen is not appropriate for everyone. A history of certain cancers, blood clots, liver disease, or unexplained bleeding may rule it out. Your provider screens for this before prescribing.

If you have a uterus, estrogen is usually paired with progesterone to keep the protocol balanced. Your provider determines what you need.

Many people notice changes over the first several weeks. Your provider adjusts your dose over time based on how you feel.

Hormone therapy is not appropriate for everyone. A licensed provider reviews your health history to determine whether treatment is appropriate for you.

Availability varies by state and is confirmed during your intake.

Compounded hormone medications are prepared by a licensed U.S. compounding pharmacy and are not FDA-approved. They may be prescribed off-label at a licensed provider's discretion when appropriate. Availability varies by state. This is educational information, not medical advice.

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Estradiol.

A licensed provider reviews your intake and prescribes estradiol if it is appropriate for you, with refills shipped to your door and your dose adjusted over time.

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Important safety information. Compounded hormone medications are prepared by a licensed U.S. compounding pharmacy and are not FDA-approved. They are prescribed only when a licensed provider determines treatment is appropriate after reviewing your health history. This page is for informational purposes and is not medical advice. Individual results vary. Hormone therapy carries risks; discuss your personal history with your provider.

Estradiol
The systemPatchGelTabletVaginal cream
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